The Casa Real of Malolos served different purposes and carried different names during the Spanish and American Periods. Built in 1580, it originally served as the seat of government of the town. It also became the town’s Casa Tribunal, Ayuntamiento, and Casa Presidencia Municipal. It served as the office of the Treasury and the office of the town’s gobernadorcillo during the Spanish period.
The building housed the National Printing Press during the First Philippine Republic where the revolutionary organs La Independencia, El Heraldo de la Revolucion, Kalayaan and Kaibigan ng Bayan were printed.
When the Americans captured Malolos, Casa Real became the seat of their Military Government. It was turned into a hospital in 1923 and later became an annex of the Bulacan High School in 1941. It housed the Japanese Chamber of Commerce during the Japanese Occupation.
One of the permanent exhibits in Casa Real Shrine are relics of the Brave Women of Malolos of whom Rizal wrote a poem to honor their courage of setting up a school against objections from the towns friars.